Orthotopic Animal Model

Aids both independent & joint drug development via a global standard of orthotopic animal model services

Simulates the human body environment by injecting cancer cells into corresponding target organs in mice

Aims to create a model mirroring actual patient tumor tissues by interacting with the microscopic tumor environments.

• Orthotopic Animal Model

  Comparison Items

  Orthotopic Animal Model

• Subcutaneous Tissue

  Spread of generated area to other organs

  Same organ

• Low

  Clinical replication success rate

  High

• X

  Propagation to the identical organ

  O

• X

  Interaction with adjacent tissues

  O

In vivo Anti-Cancer Effect

Unlike the ectopic animal model, cell inhibitory activity and apoptosis efficacy were confirmed in various solid cancer cell lines.
For the ectopic animal model, drug candidate B demonstrated the most significant decrease in tumor volume. However, in the orthotopic animal model, drug candidate A achieved the best results out of the three candidates. Pancreatic Cancer Orthotopic Model Test Results by PLATBIO